Applied Liposome Research Laboratory

Applied Liposome Research Laboratory's mission is to serve suffering sick people by developing innovative liposomal formulations of drugs for targeted drug delivery. Small molecule drug candidates usually are substrates of multidrug transporters, therefore they have bad ADME/tox properties. The disadvantageous tissue distribution results in low therapeutic efficiency at the target site and often intolerable and life threatening toxic side effects in non-targeted tissues and organs. Liposomal formulations cross the barriers through pores and via vesicular transport (rafts and caveolae). Understanding of rules of vesicular transport lead to concept of targeted drug delivery, where liposomes and other nanodrugs may hit the target via passive (size dependent) and active (receptor mediated) mechanisms. These routes avoid the non targeted tissues.The Applied Liposome Research Laboratory is intensively researching the suitable formulations of passive and active targeting. In alliance with Seroscience Ltd our formulations are routinly tested for immunotoxic infusion reactions